EFFECTS OF SENSE TANKYRASE TRANSFECTION ON SMOOTH MUSCLE CELLS OF CORPUS CAVERNOSUM IN RAT
نویسندگان
چکیده
منابع مشابه
Effects of tetrandrine on cytosolic free calcium concentration in corpus cavernosum smooth muscle cells of rabbits.
AIM To study the relaxation mechanisms of tetrandrine (Tet) on the corpus cavernosum smooth muscle. METHODS The corpus cavernosum smooth muscle cells from New Zealand white rabbits were cultured in vitro. [Ca(2+)](i) was measured by Fluorescence Ion Digital Imaging System, using Fluo-2/AM as a Ca(2+)-sensitive fluorescent indicator. RESULTS Tet (1, 10 and 100 micromol/L) had no effect on th...
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BACKGROUND Patients undergoing radical prostatectomy (RP) are at high risk for erectile dysfunction (ED) due to potential cavernous nerve (CN) damage during surgery. Penile hypoxia after RP is thought to significantly contribute to ED pathogenesis. AIM We previously showed that corpora cavernosum smooth muscle cells (CCSMCs) undergo phenotypic modulation under hypoxic conditions in vitro. Her...
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Objective: The aim of this study was to determine the changes and underlying mechanisms of erectile organ structure and function in hyperlipidemic rats. Materials and Methods: Sixteen male rats were fed a normal diet to serve as controls, and the other sixteen rats were induced to develop hyperlipidemia with a high fat diet. After 4 months, the penile tissues were harvested and assessed for smo...
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Background: Phenotypic modulation within corpus cavernosum smooth muscle cells (CCSMCs) plays a critical role in the pathogenesis of erectile dysfunction (ED), yet little is known regarding the effects of plateletderived growth factor-BB (PDGF-BB) on CCSMCs phenotype. Objective: The aim of the present study was to evaluate the effect of PDGF-BB on phenotypic modulation of CCSMCs. Method: Cell v...
متن کاملExperimental model of human corpus cavernosum smooth muscle relaxation.
PURPOSE To describe a technique for en bloc harvesting of the corpus cavernosum, cavernous artery and urethra from transplant organ donors and contraction-relaxation experiments with corpus cavernosum smooth muscle. MATERIALS AND METHODS The corpus cavernosum was dissected to the point of attachment with the crus penis. A 3 cm segment (corpus cavernosum and urethra) was isolated and placed in...
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ژورنال
عنوان ژورنال: Archives of Andrology
سال: 2006
ISSN: 0148-5016
DOI: 10.1080/01485010500315727